Onchocerciasis in Ecuador: ocular findings in Onchocerca volvulus infected individuals.
نویسندگان
چکیده
منابع مشابه
Onchocerciasis in Ecuador: changes in prevalence of ocular lesions in Onchocerca volvulus infected individuals over the period 1980-1990.
Trends in prevalence rates of onchocercal ocular lesions were examined over the period 1980 to 1990 using data from two cross-sectional surveys. There was evidence for increasing prevalence of anterior chamber microfilariae, iridocyclitis, optic atrophy, and chorioretinopathy. Large increases in prevalence, in particular, were seen for posterior segment lesions: optic atrophy increased from 2.7...
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Onchocerciasis is a major cause of blindness worldwide, and much of the blindness is caused by onchocercal chorioretinitis. In an experimental animal model for ocular onchocerciasis, intravitreal injections of 10,000 live Onchocerca volvulus microfilariae isolated from infected humans into the eyes of cynomolgus monkeys (Macaca fascicularis) resulted in patchy, progressive loss of retinal pigme...
متن کاملImmunoregulation in onchocerciasis: persons with ocular inflammatory disease produce a Th2-like response to Onchocerca volvulus antigen.
To examine the role of specific cytokines in mediating the clinical manifestations of human onchocercal disease, microfilariae-positive Ghanaian subjects with inflammatory ocular disease were compared with microfilariae-positive subjects without ocular disease. Onchocerca volvulus antigen (OvAg)-stimulated peripheral blood mononuclear cells (PBMC) from subjects with disease produced significant...
متن کاملOcular onchocerciasis.
ONCHOCERCIASIS is caused by infection with the adult filarial worm Onchocerca volvulus; the microfilariae of this worm develop in the body of man and sometimes penetrate the tissues of the eye where they set up pathological changes leading to blindness; embryos may also be found in the skin, in lymph glands, in the fluid of hydroceles, and in effusions into joints. The disease has been reported...
متن کاملIvermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection.
The present study examined the quantitative and qualitative changes registered in the parasite-specific antibody response, cellular reactivity and cytokine production profile in onchocerciasis patients repeatedly treated with ivermectin over a period of 8 years. The densities of Onchocerca volvulus microfilariae (mf) in treated patients remained significantly reduced, whereas the number of perm...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1995
ISSN: 0007-1161
DOI: 10.1136/bjo.79.2.157